Phase 46 · Protein & Peptide Tools
Antibody Germline, SHM & Mutation Mapper
Map antibody variable-domain sequence differences against an explicit reference panel, and use local ANARCII/IMGT numbering when available. The tool does not call every protein difference “somatic hypermutation.”
Query antibody variable-domain protein sequence
Reference variable-domain FASTA (optional but recommended)
Try local ANARCII IMGT numbering; use legacy ANARCI V/J germline assignment if separately available
Optional nucleotide divergence / SHM-compatible comparison
Query variable-domain nucleotide sequence
Reference nucleotide sequence
I confirm this nucleotide reference is the intended germline reference
Load demo Map germline / mutations
Ready.
Scientific guardrails
Numbering output is shown only when ANARCII or legacy ANARCI is actually available.
Supplied references are ranked only within the supplied panel.
Protein differences are not automatically SHM.
SHM-compatible nucleotide divergence is reported only after explicit germline-reference confirmation.
This page complements the Antibody Sequence Analyzer; it does not repeat its developability calculations.