Phase 67 · DNA & RNA Tools
Circular DNA Canonicalization & Equivalence
Determine whether two circular DNA sequences are exactly the same molecule despite different displayed origins. Optionally treat reverse-complement representations as equivalent.
Reference circular DNA or FASTA
Query circular DNA or FASTA
Load rotation demo Compare circular sequences
Ready.
Why canonicalization matters A circular molecule has no biologically privileged “first” nucleotide. The same sequence can therefore be written with different origins. This tool uses exact rotation equivalence before declaring sequences different. Optional reverse-complement equivalence is explicit rather than assumed. This is strict sequence identity. It does not tolerate substitutions, insertions or deletions and does not establish topology or biological function.
Equivalence result
Reference canonical sequence
Query canonical sequence