Phase 8 · Batch workflow

Batch VCF Variant Analysis

Upload human GRCh38 or GRCh37 VCF variants, annotate consequences in VEP batches, filter research evidence, retrieve source-linked evidence for multiple variants, and send RefSeq-compatible variants into the Variant → Experiment workflow.

Research scope: GRCh38 and GRCh37 small sequence variants on chromosomes 1–22/X/Y/MT are supported. Multi-allelic records are split. Symbolic structural variants and breakends are skipped. GRCh38 deep evidence can include gnomAD v4; GRCh37 deep evidence intentionally omits GRCh38-only gnomAD v4. No ACMG/AMP classification is assigned.

1. Load VCF

VCF file

The file is read locally by the browser, then the VCF text is sent to the local/server Phase 8 parser.

Assembly

Choose the coordinate assembly explicitly, or use Auto when the VCF header contains a recognizable reference. gnomAD v4 deep evidence is available only for GRCh38.

VCF text

Load a VCF file or paste VCF text.

2. Batch analysis

Parsed0

Skipped0

Annotated0

Visible0

Selected0

Parsed variants are ready for batch VEP analysis.

3. Filter & review

Consequence

ClinVar

Max population AF

Predicted signal

	Variant	Gene	Consequence	Transcript / protein	ClinVar	Population AF	Predictors	Evidence	Action
Analyze variants to populate this table.